Caloric restriction mimetic

Caloric restriction mimetics (CRM) try to mimic the substantial anti-aging effects caloric restriction (CR) has on many laboratory animals. In other words, the administration of a CRM results in the same physiological changes seen in CR itself. One way CRM work is by influencing specific genes that ultimately affect either cell repair or cell death. A number of genes and pathways have also been shown to regulate the actions of CR in model organisms and these represent attractive targets for drug discovery and for developing CRM.